Chunshan gui and oatp1b1

WebChunshan Gui, a Brett Wahlgren, a Gerald H. Lushington, b and Bruno Hagenbuch a, c, * ... Inhibition of OATP1B1-mediated estradiol-17β-glucuronide uptake by 37 nuclear … WebDec 24, 2024 · Taken together with our previous results 7 that the mutations of OATP1B1*5, *15 and CYP2C9*2, *3 significantly affect the transport and metabolism of glimepiride and gliclazide, it can be deduced ...

Amino Acid Residues in Transmembrane Domain 10 of Organic …

WebFeb 8, 2008 · Chunshan Gui, a Yi Miao, a Lucas Thompson, a Bret Wahlgren, a Melissa Mock, b Bruno Stieger, b and Bruno Hagenbuch a, c ... transport, we developed Chinese Hamster Ovary (CHO) cell lines stably expressing OATP1B1 or 1B3 at high levels. OATP1B1- and 1B3-mediated estradiol-17β-glucuronide uptake was inhibited by several … WebWe have used OATP1B1- or OATP1B3-expressing Chinese Hamster Ovary cells on 96-well plates and determined uptake of fluorescein-methotrexate (FMTX). We validated the assay with known inhibitors and screened the well characterized Prestwick library of 1120 drugs. pooley clare https://blupdate.com

OATP1B3 (699G>A) and CYP2C9*2, *3 significantly influenced

WebIn this study, we investigated the molecular mechanism for this substrate selectivity of OATP1B1 by constructing OATP1B1/1B3 chimeric transporters and by site-directed … WebChunshan Gui1, Amanda Obaidat1, Rathnam Chaguturu2,3 and Bruno Hagenbuch*,1,2 ... hibitors for OATP1B1 and OATP1B3. We have used OATP1B1- or OATP1B3-expressing Chinese Hamster Ovary cells ... 2010, Volume 4 Gui et al. used this assay to screen the Prestwick library for modulators (inhibitors or stimulators) and confirmed several hits by WebAug 6, 2024 · A number of drug-drug and drug-food interactions have been associated with OATP1B1 and 1B3, affecting the pharmacokinetics and pharmacodynamics of their substrate drugs. 8–16 It has also been reported that many natural substances present in food or dietary supplements such as flavonoids could intact with OATP1B1 and 1B3 and … pooleye above ground pool alarm

Development of a cell-based high-throughput assay to screen for ...

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Chunshan gui and oatp1b1

Human Organic Anion Transporting Polypeptides 1B1, …

WebChunshan Gui Organic anion transporting polypeptide 1B1 (OATP1B1) is a key hepatic uptake transporter whose inhibition could lead to adverse drug-drug and drug-food interactions. WebJianqing Ruan, and Chunshan Gui* Cite This: ACS Omega 2024, 6, 35844−35851 Read Online ... (OATP1B1), OATP1B3, OATP2B1, Na+/taurocholate cotransporting polypeptide (NTCP), organic cation transporter 1 (OCT1), and OAT2, have been investigated to see whether they are involved in the hepatic uptake of PSP. An in vitro cell-based study ...

Chunshan gui and oatp1b1

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WebMar 1, 2010 · Comparison of OATP1B1- and OATP1B3-mediated transport of fluorescent substrates. Uptake was measured with 1 µM of the indicated fluorescent compounds on 24-well plates for 30 min. Values are means ± SE of two combined independent experiments each performed with triplicate determinations. WebAug 9, 2008 · Europe PMC is an archive of life sciences journal literature. Search life-sciences literature (Over 39 million articles, preprints and more)

WebSep 16, 2009 · The liver-specific organic anion transporting polypeptides OATP1B1 and OATP1B3 are highly homologous and share numerous substrates. However, at low concentrations OATP1B1 shows substrate selectivity for estrone-3-sulfate. WebNov 1, 2009 · Search worldwide, life-sciences literature Search. Advanced Search

WebDec 24, 2024 · Taken together with our previous results 7 that the mutations of OATP1B1*5, *15 and CYP2C9*2, *3 significantly affect the transport and metabolism of glimepiride … WebAug 6, 2024 · A number of drug-drug and drug-food interactions have been associated with OATP1B1 and 1B3, affecting the pharmacokinetics and pharmacodynamics of their …

WebSep 2, 2008 · Three-dimensional model of the OATP1B3/CCK-8 complex. A side view (A) and a view from the intracellular side (B) are presented. Helical segments of the protein are shown in cylinders; the three residues Y537, S545 and T550 in TM10 are shown in ball-and-stick and in orange; CCK-8 is shown in ball-and-stick and in purple.

WebFeb 8, 2008 · OATP1B1- and 1B3-mediated estradiol-17beta-glucuronide uptake was inhibited by several pregnane X receptor ligands in a concentration dependent way. … pooley country park tamworthWebThis type of analysis has been previously successfully used to determine the type of interaction of OATP1B1 with a wide range of physiological substrates and fibrates (Gui et al., 2009; Yamazaki ... pooley country park birminghamWebMay 29, 2014 · Chunshan Gui Authors' Affiliations: ... Transport of paclitaxel, docetaxel, and cabazitaxel was studied in vitro using various cell lines transfected with OATP1B1, OATP1B3, or the rodent equivalent OATP1B2. Pharmacokinetic studies were done in wild-type and OATP1B2-knockout mice in the presence or absence of polysorbate 80 (PS80) … pool eyeball replacementWebApr 1, 2010 · Author links open overlay panel Chunshan Gui a, Bruno Hagenbuch a b. Show more. Add to Mendeley. Share. Cite. ... (Hagenbuch and Gui, 2008, König et al., 2006). Mice and rats have only a single transporter in the OATP1B family that is the ortholog of human OATP1B1 and OATP1B3 which arose through gene duplication after … pooleye pe12 installationWebAbstract: The two organic anion transporting polypeptides (OATPs) 1B1 and 1B3 are expressed at the sinusoidal membrane of hepatocytes. They have a broad and overlapping substrate specificity and transport many endobiotics and drugs. shards of earth summaryWebDec 16, 2024 · OATP1B1, OATP1B3, and OATP2B1, with OATP1B3 showing the highest transport efficiency. The Kmvalues for OATP1B1-, OATP1B3-, and OATP2B1-mediated PSP uptake were 11.3 ± 1.5, 7.0 ±1.5, and 5.1 ±1.0... shards of eradine cheatsWebJun 30, 2011 · At present, Chunshan Gui et al. have confirmed that ursolic acid was the selective OATP1B3 and OATP1B1 inhibitor (Chunshan et al. 2010). Therefore, the drug … shards of earth book review